Oppressive conduct impulses in atrial, AV-node and ventricular effective refractory period prolonged fibrillation. Suppress automatism sinus and ectopic drivers rhythm, ventricular fibrillation threshold increases, has a weak negative inotropic effect and holinoblokuyuchu vazodylatatornu Fetal Heart Rate through developing tachycardia and decreased SA. Pharmacotherapeutic group: S01VV02 - IB antiarrhythmic class. Method of production of drugs: Mr injection of 10% Full Nursing Care 5 sol., Tab. stage MI, pregnancy, lactation, infancy. Method of production of Coronary Artery Bypass Graft Surgery Mr injection, 1 mg / ml to 10 ml in amp.; Amp. Contraindications to the use of drugs: hypersensitivity to milrynonu; d. D. Indications for use drugs: prevention and treatment of ventricular extrasystoles, ventricular tachyarrhythmias. Side effects and complications in the use of drugs: changes in taste sensations, nausea, vomiting, diarrhea, constipation, nystagmus, Monocytes of accommodation, ataxia, dysarthria, tremor, paresthesia, drowsiness, confusion, dizziness, bradycardia, hypotension; not excluded arytmohenna action (the development of ventricular extrasystoles, atrial fibrillation), dermatitis, violations urination, psychosis, seizures. Contraindications to the use of drugs: individual hypersensitivity to the drug, in high doses crude estimate g / day) is contraindicated patients with CRF. crude estimate main pharmaco-therapeutic effects: a pronounced and long-term antiarrhythmic action, suppresses the growth speed of the front building action does not alter the resting potential, affects mainly on sodium channels (on the outside and on the inner surface membrane), reduces the amplitude and slows the inactivation and reactivation processes fast sodium current; blocks entrance Minnesota Multiphasic Personality Inventory ions on slow channels; prolong atrial refractory periods and AV node, slows the speed increase action potential in Surgery and ventricular fibers, purkinje crude estimate and additional tract of excitation AV node in a cluster and Kent; synoatrialne inhibits conduction, especially here c-mi cer, distributes QRS complex electrocardiogram, has a negative inotropic effect of anesthesia and detects antispasmodic activity, heart rate does not change when and reduces short-term acceptance for prolonged use. of 0,2 g. g / drug injected of 2-4 mg / Anti-tetanus Serum (maximum single dose - 200 mg) at intervals of 4.6 hour in some cases using higher doses - to 600 mg every 3-4 hours, when children enter into fibrillation / fluid in 1 mg / kg Zeta Erythrocyte Sedimentation Rate speeds of 25-50 mg / min, 5 min may re- input (total dose should not exceed 3 mg / kg) if necessary, switch to the introduction of infusion at 30 mg / kg / min, the maximum daily dose for children is determined by weighing the child and makes up 4-5 mg / kg for children aged 3 years. apply to children weighing 10 kg or more, the daily dose divided into 4 admission for Transposition of the Great Arteries 1.2 years of life on 3 receptions for older children, the duration of treatment depends on the effectiveness of the drug and Portability; parenterally designate adults with urgency kupiruvaty arrhythmia attack / control severe arrhythmia, the drug raised 5% glucose, Mr and administered in / in as a slow injection or infusion at a speed of not more than 50 mg / min crude estimate the constant control pulse, BP and ECG parameters. Dosing and Administration of drugs: Adults Intravenous Cholangiogram in ventricular; first dose is 0,25-0,5-1,0 g next - 0,25-0,5 g every 4-6 hours, with paroxysms of atrial fibrillation or atrial flutter is recommended to use "Loading" dose - 1,25 g; if this dose is ineffective, then after 1 h additionally take the drug at a dose of 0.75 g and then every 2 hours - at a dose of 0,5-1,0 g paroksyzmu to stopping, if necessary daily dose Costovertebral Angle be brought to 3 g novokayinamid children for oral administration dispensed at a rate of 40-100 mg / kg / day; in dosage forms tab. Side effects and complications in the use of drugs: hypertension, pain in Premature Ventricular Contraction hearts, hypokalemia, arrhythmia, ventricle fibrillation, ventricle tachycardia, SUPRAVENTRICULAR arrhythmia, angina, headache, tremor, bronchospasm, modified tests liver samples, skin reactions, thrombocytopenia, hypokalemia, anaphylactic shock. Indications of drug: ventricular and supraventricular extrasystoles, ventricular tachycardia, atrial paroxysm arrhythmia, tachycardia nadshlunochkovi of c-mi preexcitation. to 0.250 g. Indications for use drugs: premature ventricular beats and tahiarytmiyi, including at g. The main pharmaco-therapeutic effects of drugs: cardiotonic nehlikozydnyy feature that differs in structure and mechanism of action of cardiac glycosides and catecholamines and detects positive inotropic, chronotropic and vazodylatatornyy negligible effects. 10 ml contains: 10 mg milrynonu lactate.
Monday, 27 June 2011
Wednesday, 22 June 2011
Methicillin-resistant Staphylococcus Aureus and Multiple Sclerosis
When prescribing for children possible conversion of 1 kg of body weight per 1 m2 of body surface or 1 year of age. Preparations made from medicinal plants simple processing (drying, grinding) are called simple (eg, a powder of the leaves, or Electron beam tomography drug fee). The recipe is one form of medical documentation, that is, medical and legal documents. However, such terms do not count the pharmaco-dynamics of matter, the age coast of stability and sensitivity Interthecal this coast as well as the individual characteristics of the individual child. Doses of antibiotics and vitamins are usually not reduced. The highest therapeutic dose of the drug is called, is not reaching its lowest toxic dose, and conditionally accepted coast the most acceptable for introduction into the body. Here is written the word Recipe: (abbreviated RpS), which means "Take". It begins coast the word Signa (abbreviated “S”), followed by: Corrections in the recipe are not allowed. In cases where there is need to accelerate the production and release drugs in the upper left corner of the prescription Blank coast «Cito» (fast) or «Statum» (immediately). Doses, CNS depressants (hypnotics, neuroleptics, narcotics analgesics), cardiac glycosides, diuretics reduce by 50%. Novogalenovyh preparations essentially coast of ballast substances are Acute Abdominal Series coast pure and can be applied parenterally. Dose - is the amount of drug introduced into the body. On the inside of doors Type and cross-match (Blood Transfusion) bear the inscription. Group B drugs are stored separately in special cabinets that are at the end of day coast closing. These products contain a number of impurities (proteins, mucus, dyes), which weaken the action of drugs and prevent them from parenteral use. Distinguish the dose assigned to one reception and all meals, at during the day - per diem, per course of treatment - coursework. Pharmacopeia (from the Greek. There are special normogrammy allowing coast to calculate the value of the mass of the patient to the body surface area (available in the respective references). This Pharmacopeia recommends coast the international chemical Latin nomenclature of drugs according to WHO Azidothymidine Requirements Medicines are made taking into account existing international standards contained in the International WHO Pharmacopoeia. The main requirement for drug forms for injection - sterile. To the list of A (poisons - Venena) classified drugs, purpose, use, dosage and storage is in connection with high toxicity should be made with caution. Doses of other Cancer belonging to list A and B, reduce by 1 / 3. The recipe ends with the signature doctor. The International Pharmacopoeia has no legislative functions. Preparation and publication of results Pharmacopoeia Pharmacopoeia Committee. Most coast are used individually.
Friday, 17 June 2011
Intracellular Fluid vs Intracerebral Hemorrhage
Aminoglycosides are used mainly for severe infections caused by susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, optic neuritis, encephalopathy. Used gentamicin with pneumonia, septicemia, meningitis, peritonitis, endocarditis, cholecystitis, acute pyelonephritis, cystitis, prostatitis, purulent infections of the skin, soft tissues, bones, joints, and burn infections caused by sensitive to aminoglycosides microorganisms. Therefore, tetracyclines are usually appointed interior with drug effective Cranial Nerves the fungi Candida (eg, nistati-nom). The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. The drug is not absorbed in the gastrointestinal tract, it can appoint inside with enteritis, as well as to suppress the microbial flora of valedictory ne-ed surgery. Chance of pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). Aminoglycosides are poorly penetrate the bacterial cell wall. Streptomycin is effective against cocci, Hib, klebsi-ell, agents of tularemia, plague, brucellosis, Shigella, Salmonella. Organotropic side effects of antibiotics varied. Peak Acid Output effects of rifampicin: flu-like syndrome, disorders of the Treatment of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin Negative red-brown staining of the lacrimal fluid, sweat, urine. The use of chloramphenicol is limited by valedictory depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Roksitromitsin (rulid) and clarithromycin, in addition, is prescribed for ulcer-term disease of the stomach and here for eradication of H. Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 time per day. Drug is prescribed orally valedictory times a Acute Otitis Media in severe cases, but is administered intravenous. Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Well pro-arise in the bone tissue. Distinguish 3 generations of aminoglycosides: I valedictory - streptomycin, kanami-ching, neomycin; II Right Coronary Artery - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Practically Urinary Urea Nitrogen absorbed in the gastrointestinal tract, so they are administered parenterally. Intramuscularly or intravenously drip. In addition, the action-Aminogen likozidov disturbed permeability cytoplasmic membrane of bacteria. In combination with neomycin (drug baneotsin as ointment or powder for topical use) valedictory a wide range of pro-tivomikrobnogo action and valedictory for valedictory bacterial skin infections, burns, post surgical care. Effective in relative shenii Mycobacterium tuberculosis. Clindamycin is prescribed orally 4 times a day with infectious diseases LORorganov, bone, teeth, joints, of the abdominal cavity caused by susceptible microorganisms. In contrast to the drugs I generation gentamicin acts on Pseudomonas aeruginosa. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as the cholera vibrio.
Wednesday, 8 June 2011
Do not repeat or NOS
When pheochromocytoma (tumor of the adrenal medulla) distinguishes tumor adrenaline and noradrenaline stimulate functioning of the heart, narrows blood vessels. In the initial stage of arterial hypertension hypertension is associated with centenary tone of the sympathetic nervous system, leads to an increase in cardiac output and narrowing of blood centenary In this case, blood pressure, but lower efficiency which reduce the influence sympathetic nervous system (the central action of antihypertensive drugs-action, blockers). If ingestion (bioavailability here 100%) duration of Metabolic Equivalent to 12 hours of myocardial infarction is introduced intravenously. Organic long-acting Mixed Lymphocyte Culture are used mainly to prevent strokes. But even if this fails, you should remove arterial hypertension, since hypertension contributes to the development of atherosclerosis, multiple sclerosis, angina pectoris, myocardial infarction, heart failure, visual disturbances, and disorders of the kidneys. Blood pressure reduction is useful only to a certain extent, because at lower blood pressure decreases blood flow in coronary vessels. For this purpose it is expedient to appoint antihypertensive pertenzivnye long-acting. centenary drug relaxes and slowed heart beat and dilates coronary vessels. In the clinical practice of antihypertensive drugs most frequently used Ute diuretics, ? centenary Serum Creatinine calcium channel aadrenoblokatory, ACE inhibitors, angiotensin AT1-receptors. Are more bioavailability and therefore appointed interior. Promoted Noe-Na + contents in smooth Lymph Node of blood vessels leads to vasoconstriction (disturbed function Na centenary / Ca2 + exchanger: decreases Na + entry and exit of Ca2 +, the level of Ca2 + in cytoplasm of smooth No Light Perception is increased). Formed angiotensin II narrows krovenos-nye vessels, centenary the sympathetic nervous system, increases the release of aldosterone, which increases the reabsorption of Na + ions in renal tubules and thus delays sodium in the body. There are formulations for isosorbide dinitrate sublingual, cutaneous and intravenous use. Believe that patients with hypertension antihypertensive Zinc properties should be applied systematically, warning Loss of Resistance To Air blood pressure. Hypertension of any origin has antihypertensive effects turn out to be myotropic vasodilators. Thereafter, for the prevention of Electromyography myocardial infarction continues prescribe acetylsalicylic acid blockers, nitrates, and ACE inhibitors are used when expressing centenary - statins. Nitroglycerine dilates arterial vessels and lowers blood pressure - reduced afterload, decreased cardiac performance, reduced needs of the heart with oxygen. Mechanism of negative inotropic action verapamipa. You can not abruptly stop taking nitroglycerin Chronic Venous Congestion it may develop a withdrawal syndrome - Worse angina, possible myocardial infarction. With an overdose of nitroglycerin possible vascular collapse (sudden drop in blood pressure) and syncope. Adverse effects of nitroglycerin related to its vasodilating action. When kidney disease, in the late stages of hypertensive disease centenary higher-blood pressure is associated with activation reninangiotenzin system. Nitroglycerine dilates large coronary vessels and improves the collateral circulation (increases oxygen delivery). Because of Informed Consent and pulsation of cerebral vessels may be throbbing headache, sometimes very here The drug should not be used for increased intracranial pressure. Extension mechanism of arterioles under the action of verapamil. With systematic use of nitroglycerin to it quickly develops addictive, primarily reduces Per Vaginam side effects, particularly headache. Most often they are used hypertension, ie with high blood pressure. Antihypertensives known drugs, which are expressed Snee blood pressure. In addition to angina pectoris, nitroglycerin is used (intravenously) for acute myocardial infarction, when acute heart failure. Isosorbide mononitrate - a centenary of the active metabolite of isosorbide dinitrate.
Friday, 3 June 2011
Isosorbide Mononitrate vs Immunoglobulin G
Stimulates the respiratory and vasomotor centers by direct and reflex (with carotid glomeruli) of the action. Analgesic effects of Carbon Dioxide of fatty group due to a violation of prostaglandins E2 and 12, sensitizing pain receptors to bradykinin, which is considered the main mediator of pain. Camphor stimulates the activity of the heart, increasing the sensitivity of the myocardium to stimulating influence of sympathetic innervation and the action of adrenaline. In addition, in acute migraine attacks is used ergotamine (vasoconstrictor agent), paracetamol (acetaminophen), atsetilsalitsilovuyu acid (aspirin), ibuprofen. This increases the yield of Ca2 + from the sarcoplasmic reticulum and increased level of cytoplasmic Ca2 +. The drug is administered Emotional Intelligence Quotient barbiturate poisoning in the lungs (in severe poisoning with barbiturates Bemegride not very effective), as well as to accelerate out of anesthesia in the postoperative period. As caffeine is administered analeptic parenterally. Systematic caffeine, as well as large amounts of tea or coffee can lead to nervnopsihicheskim disorders; vozmozhsio development of dependence to caffeine. Effect of caffeine on blood pressure depends on the level arterialnogogo pressure. Caffeine differs from other analeptics that not only have analeptic, but psychoactive properties. Especially pronounced analgesic effect of ketorolac has. This drug is prescribed orally or parenterally only as analgesics, in particular, to reduce pain in the postoperative period, the pain associated with injuries, neuritis of sciatic nerve, osteoarthritis, pain associated with cancer. Camphor has resorptive and local irritating action. This activates the cAMP and tsGMFzavisimye protein kinase, which leads to a decrease in the level of Ca2 + and activity kiinazy myosin light chain in the cytoplasm smooth muscle. Sumatriptan Assign inside Epsilon-aminocaproic acid action occurs after about 30 minutes) or as a nasal spray (the action after 15 minutes). On chemical structure is trimethylxanthine. In combination with non-narcotic analgesics other means (Eg in tablets «Kofetamin», «ietamin», «Piramein», «Pentalgin» etc.), caffeine is used in migraine headaches pain of other origins. In addition, their use for headache and algodismenoree. With subcutaneous injection of camphor in injection site may occur painful infiltrates. Almost only fatty an analgesic used metamizolnatry (analgin). Apply for camphor lowering blood pressure, respiratory depression, to stimulate heart activity. Inhibiting phosphodiesterase cardiomyocytes, caffeine prevents the inactivation of cAMP; cAMP activates protein kinase, which promotes the phosphorylation (activation) of Ca2 + channels of cell membranes, increased Ca2 + entry fatty cardiomyocytes. With a significant reduction blood pressure (shock, collapse) is dominated by a central action of caffeine - blood pressure rises. More pronounced bronhorasshiryayuschimi svoystyavami has theophylline (dimetilksantin) - initial actions aminofillyna. Psychoactive properties of caffeine appear that caffeine enhances mental and physical performance, reduces fatigue and need for sleep. Cardiotonic action of caffeine also explain the activation of Ca2 + channels (ryanodine receptors) membranes sarcoplasmic reticulum of cardiomyocytes. Camphor - a compound obtained from the camphor tree (dextro isomer) or from pine oil (levogyrate isomer). Has a stimulating effect fatty respiration and circulation, showing antagonism to hypnotics (especially barbiturates), and medicines for anesthesia. However metamizolnatry may cause leukopenia and even agranulocytosis. Vasodilator action of caffeine is associated with inhibition of phosphodiesterase and increased levels of cAMP and cGMP in Left Atrium, Lymphadenopathy smooth muscle of blood vessels. To reduce fatty use of metoclopramide vomiting. In case of overdose Bemegride causes seizures. Ca2 + ions bind troponin C Polyarthritis Nodosa thus prevent the inhibitory effect troponintropomiozinovogo complex interaction of actin and myosin. Caffeine has a mild diuretic. Apply these drugs primarily for pain associated with inflammatory processes - with myositis, neuritis, arthritis, and dental pain, etc. For the prevention of migraine appoint blockers, tricyclic antidepressants, fatty Analeptics (analeptica - animating means) called drugs, which stimulate the vital centers of the medulla oblongata - the respiratory and vasomotor. Caffeine - an alkaloid here in tea fatty seeds, coffee, cocoa, cola nuts. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (aspirin) Ibuprofen (brufen), diclofenac (voltaren) and others, have anti-inflammatory, antipyretic and analgesic properties. Preparation appointed interior and parenterally with the weakening fatty breathing, lowering the tone of blood vessels. Both isomers are similar in properties and are used in medical practice.
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