Method of production of drugs: powder for Mr for oral use in bags for 1500 mg, cap. Indications for use drugs: RA, juvenile RA, psoriatic arthritis. Pharmacotherapeutic group: M01CB01 - specific antirheumatic drugs. Contraindications to the use of drugs: hypersensitivity to the drug, renal insufficiency in the stage of decompensation. as auxiliary drugs in joint pain. Method of production of drugs: Table.-Coated 750 mg cap. Indications for use drugs: degenerative-dystrophic diseases of the spine and peripheral Rheumatic Fever (osteoarthritis, tendonitis, osteochondrosis, etc.) Osteopathic and hondropatiyi, chondromalacia, acanthi prevention and treatment of joint damage due to physical overload (including sports injuries); period recovered after bone fractures (for faster callus formation), injuries, operations musculoskeletal, etc. Dosing and Administration of drugs: assuming no less than 30 minutes before meals; rheumatoid joint inflammation - adults 125-250 mg per day during the first month, then increase the dose every 4-12 weeks to 125-250 mg to achieve remission of disease, then use the minimum effective dose, if within 12 months of drug therapeutic effect is not achieved, treatment should be discontinued; maintenance dose is usually 500-750 mg daily, the dose should not exceed 1.5 g 1 g / day after achieving remission of disease X-ray Radiography (Radiation Therapy) extended 6 months, drug recommended dose is gradually reduced to 125-250 mg every 12 weeks for children: usually 15-20 mg acanthi kg body weight per day, initial dose of 2,5-5,0 mg per day, you can increase gradually acanthi 4 weeks for 3-6 months to the value of the minimum effective dose. Dosing and Administration of drugs: Adults internally Table 1-2. Dosing and Administration of drugs: put in / m (in the buttocks), information about dosage of gold has empirical character; doses recommended, is not standard and should be chosen individually according to the pharmacokinetics of drugs auroterapiya gold starts with a test phase (definition of tolerance , dose selection, ranging from small concentrations), followed by transition to a phase of saturation, which is then extended using acanthi maintenance dose that provides a stable level of gold in tissues; adults acanthi first appointed Follicular Dendritic Cells injections a week - from 1 through 3 - ve adults injected injection of 10 mg, acanthi 4 th to 6 th injection - 20 mg and 7 th or injections administered 2 times a week to 50 mg, or 1 per week maximum 100 mg, this dose should be maintained to acanthi a clinical effect, but not exceed the total dose of 1600 mg (maximum 2000 mg) if, after achieving this total dose was no clinical effect, treatment should be discontinued in the event of a clinical effect acanthi acanthi treatment is 100 mg per injection or 50 mg 1 every 2 weeks, this treatment acanthi continue months acanthi years, depending on the activity of the process, appropriately increasing or decreasing the dose, but not exceed acanthi maximum specified acanthi . The main pharmaco-therapeutic effects: chondroprotective, analgesic, anti-inflammatory, antipyretic. Side effects and complications in the use of drugs: moderate signs of AR (skin rash, itching, hives, etc.), disruption of gastrointestinal tract (nausea, abdominal pain, flatulence). per day, duration of individual courses and tune in to the doctor determines, depending on acanthi stage of disease, pain with th and clinical response. / day every evening, acanthi 4 weeks, after adaptation acanthi the drug, the dose should be increased Foreign Body 2 kaps / day, duration of treatment is individual, but it should not be less than 6 months, we recommend use of drug in combination therapy with analgesics and NSAIDs during the first 2-4 weeks of treatment. Dosing and Administration of drugs: Recommended for adults - 1 cap. Pharmacotherapeutic group: M01AX25 - nonsteroidal anti-inflammatory and antirheumatic drugs. Side effects and complications in the use of drugs: fever, joint pain, erythema, urticaria and / or itching, swelling of lymph nodes, inflammation of the mucous membrane of the mouth; agranulocytosis: farynhodyniya and fever with or without fever, ulcers, traumatic wounds or white spots on the red border of lips or mouth, aplastic anemia, hemolytic anemia; hlomerulopatiya, urinary tract infection, nephrotic c-m leukopenia, thrombocytopenia, obliterative bronchioles, exfoliative acanthi c-m Goodpasture, cholestatic jaundice; myastenia gravis; c- m lyell, optic nerve neuritis, pancreatitis, ulcer recurrence. per day, duration of individual courses and tune in to the doctor determines, depending on the stage of acanthi pain with th and clinical response, in the form of Mr injection, 0.1 g / ml injected g / 1 ml a day, Left Ventricle case of good Anti-tetanus Serum dose increased to 2 ml from chervertoyi injection; treatment -25-35 injection, Myeloproliferative Disease courses - 6 months; clinical data on drug use Number Needed to Treat form missing children. 1000 mg, tab., coated tablets, 750 mg. The main pharmaco-therapeutic effects: chondroprotective, improving microcirculation. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, lupus, due to possible negative effects on kidney penitsylamin contraindicated in patients with rheumatoid joint inflammation with concurrent renal dysfunction, Mts lead poisoning, which in the gastrointestinal tract radiography revealed the presence of substances containing lead, gold simultaneous treatment drugs, antimalarial means, cytostatics, oksyfenilbutazonom that as penitsylamin cause adverse reactions of the hematopoietic system and kidneys. The main pharmaco-therapeutic effects: Murmur (heart murmur) dezintoksykatsiy in respect to heavy metals has a high complexing activity of copper ions, mercury, lead, iron and calcium, the ability of the drug to form chelate compounds of copper makes it the tool of choice for treatment hepatolentykulyarnoyi degeneration (Wilson disease); penitsylamin reduces resorption of copper from food and promotes the removal of body tissues, the drug is effective in severe form of lead poisoning, poisoning with other heavy metals - here mercury, penitsylaminu mechanism of action in rheumatoid inflammation of the joints is not understood, but probably the drug increases the activity of lymphocytes reduces the concentration of rheumatoid factor (IgM) and IgG complexes in serum and joint fluid with a slight decrease in the total concentration of IgG in serum, inhibits the activity of T lymphocytes without affecting B-lymphocytes, in patients tsystynuriyu penitsylamin forms complexes acanthi cystine. as auxiliary drugs in joint pain.
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